The survival, health and well-being of women, children and adolescents are essential to ending extreme poverty, promoting development and resilience, and achieving the SDGs. The Global Strategy takes a life-course approach that aims for the highest attainable standards of health and well-being—physical, mental and social— at every age. In recognition of this, the updated Global Strategy sets out a vision, guiding principles, three objectives and a set of core targets, in line with the SDG framework. It identifies key actions and lays the groundwork for countryled implementation planning. The Strategy is fully aligned with the priorities of the SDGs, and builds on the evidence of what is needed and what works. It encompasses all locations, social groups and settings, in particular marginalized, excluded and hard-to-reach communities.