This brief, developed by the Cross-Sectoral Skills for Youth CoP, offers an overview of current research findings on cross-sectoral skills development; summarizes promising practices, implementation challenges, and unanswered questions about cross-sectoral youth programs; and concludes with three case studies that describe the impacts of taking a cross-sectoral approach on youth. The brief was developed collaboratively after a July 17, 2019, meeting in Washington, DC, titled “Lessons Learned in Achieving a Cross-Sectoral Impact.” The meeting attracted more than 60 participants, including researchers; leaders of Positive Youth Development (PYD) programs; and representatives from USAID, other donors, and youth-led organizations.