The purpose of this learning agenda is to define priority questions in the field of Positive Youth Development (PYD) in low and middle-income countries (LMICs). This PYD learning agenda builds upon the findings of the Systematic Review of PYD Programs in LMICs that highlighted gaps in the evidence for what works and for whom. It was developed in consultation with youth-serving and youth development practitioners, researchers, evaluators, and funders. The primary goal of the learning agenda is to provide collective guidance for a common agenda to address evidence gaps and invest in evidence-building activities related to PYD. This learning agenda also provide guidance for potential ways to answer those questions. The main audiences for the learning agenda are those who design, implement, and evaluate youth programs. While developed by YouthPower Learning with funding from the United States Agency for International Development (USAID), anyone who works with youth in LMICs can respond to this learning agenda and advance the PYD field.