This brief describes key considerations and lessons learned for USAID Missions in conducting youth assessments. This information is meant to support USAID staff as they plan, implement, and leverage findings from youth assessments to inform their Mission’s programming. It draws upon the 17 youth assessments conducted under the contracts, YouthPower Learning and YouthPower2: Learning and Evaluation (YP2LE), for USAID/Missions from 2015-2020. Lessons learned from team leads, USAID Washington staff members, YouthPower staff, and USAID Mission office leads and staff members are included.